GENERAL CATALOGUE
ISM012-042
HY-170522 · 5 mg
MedChemExpress · Cat: HY-170522
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Catalog No: HY-170522
CAS No: 2924181-80-4
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
ISM012-042 is an orally active PHD1 and PHD2 inhibitor with IC50 values of 1.9 and 2.5 nM, respectively. ISM012-042 2.5 ?M can protect Caco-2 cells from DSS-induced barrier disruption. In lipopolysaccharide LPS -induced mouse bone marrow-derived dendritic cells BMDC , ISM012-042 has anti-inflammatory effects and can dose-dependently reduce the expression of IL-12 subunit IL-12p35 and TNF. ISM012-042 restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 can be used for intestinal mucosal repair and research into immune diseases.
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