Isomangiferin

Description

Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin HY-N0290 . Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-?B signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 HSV-1 . Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells BMSCs and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.