Isotoosendanin

Description

Isotoosendanin is an orally active TGF?R1 inhibitor and abrogating its kinase activity IC50 = 6732 nM . Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-?-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer TNBC cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and ?-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer NSCLC , TNBC and inflammation.