GENERAL CATALOGUE
ISRIB
HY-12495A · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-12495A
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Catalog No: HY-12495A
CAS No: 548470-11-7
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
ISRIB is a brain-penetrant inhibitor of integrated stress response ISR . Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research.