GENERAL CATALOGUE
ITI-214 free base
HY-12501 · 5 mg
MedChemExpress · Cat: HY-12501
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medchemexpress.com/ITI214-free-base.html
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Catalog No: HY-12501
CAS No: 1160521-50-5
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
ITI-214 free base is a potent, CNS-active, orally bioavailable PDE1 inhibitor Ki of 58 pM with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 free base inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 free base shows efficacy in various animal models of motor and cognitive functions.
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