GENERAL CATALOGUE
ITI-214
HY-12501A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-12501A
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Manufacturer product page
medchemexpress.com/ITI214.htmlCatalog No: HY-12501A
CAS No: 1642303-38-5
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor Ki of 58 pM with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions.
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