Ivaltinostat

Description

Ivaltinostat CG-200745 is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 Waf1/Cip1 proteins. Ivaltinostat enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine HY-16138 and 5-Fluorouracil 5-FU; HY-90006 . Ivaltinostat induces apoptosis and has anti-tumour effects.