GENERAL CATALOGUE
JAK-IN-40
HY-170927 · 50 mg
MedChemExpress · Cat: HY-170927
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Manufacturer product page
medchemexpress.com/jak-in-40.htmlCatalog No: HY-170927
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
JAK-IN-40 Compound 46 is the inhibitor for JAK that inhibits JAK1, JAK2 and JAK3 with IC50s of 0.022, 0.759 and 1.601 ?M, respectively. JAK-IN-40 inhibits the phosphorylation of STAT3. JAK-IN-40 inhibits the proliferation of cancer cell Ba/F3 and JAK1-TEL Ba/F3 with GI50 of 0.614 ?M and 0.193 ?M. JAK-IN-40 arrests cell cycle of H1975 and H2087 at G2/M phase, induces apoptosis. JAK-IN-40 exhibits a synergistic antitumor effect with Osimertinib HY-15772 .
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