JAK2 Mouse Monoclonal Antibody

Description

EnkiLife offers the JAK2 Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for IHC application. Alternative Names of Immunogen: JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:50-1:100 Background: Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Research Area: PI3K-Akt signaling pathway,Jak-STAT signaling pathway