GENERAL CATALOGUE
JAK3-IN-18
HY-174999 · 50 mg
MedChemExpress · Cat: HY-174999
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Manufacturer product page
medchemexpress.com/jak3-in-18.htmlCatalog No: HY-174999
CAS No: 2914873-59-7
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
JAK3-IN-18 is an orally active JAK3 and TEC inhibitor, with IC50s of 0.5391 nM and 12.40 nM, respectively. JAK3-IN-18 demonstrates outstanding selectivity over AK1, AK2, and TYk2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 demonstrates excellent therapeutic efficacy in the experimental autoimmune encephalomyelitis EAE mouse model. JAK3-IN-18 can be used for the study of multiple sclerosis.
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