GENERAL CATALOGUE
JB170
HY-141512 · 5 mg
MedChemExpress · Cat: HY-141512
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Catalog No: HY-141512
CAS No: 2705844-82-0
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
JB170 is a potent and highly specific PROTAC-mediated AURORA-A Aurora Kinase degrader DC50=28 nM by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A EC50=193 nM over AURORA-B EC50=1.4 AAasAasAAmuM . JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase.
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