GENERAL CATALOGUE
JCS-1
HY-164977 · 5 mg
MedChemExpress · Cat: HY-164977
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Catalog No: HY-164977
CAS No: 3093519-24-2
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
JCS-1 is a potent DcpS PROTAC degrader. JCS-1 non-covalently binds DcpS with a RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 promotes ubiquitination and degradation of DcpS at nanomolar concentrations DC50 in MOLM-14 cells: 87 nM . JCS-1 can be used for the research of AML and other DcpS-dependent genetic disorders Pink: DcpS ligand HY-102020 ; Blue: E3 ligase VHL ligand HY-151227 ; Black: linker HY-141230 .