GENERAL CATALOGUE
JH-II-127
HY-16936 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-16936
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Catalog No: HY-16936
CAS No: 1700693-08-8
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
JH-II-127 is an orally active, highly potent, selective and brain-permeable LRRK2 inhibitor, with IC50s of 6, 2 and 48 nM for wild-type LRRK2 and LRRK2-G2019S and mutant LRRK2-A2016T. JH-II-127 inhibits Ser935 phosphorylation in all tissues of mice, including the brain. JH-II-127 can be used in the study of parkinsons syndrome.
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