GENERAL CATALOGUE
JH-XI-10-02
HY-111518 · 1 mg
MedChemExpress · Cat: HY-111518
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medchemexpress.com/JH-XI-10-02.htmlCatalog No: HY-111518
CAS No: 2209085-22-1
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.
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