GENERAL CATALOGUE
JH295 hydrate
HY-116423A · 1 mg
MedChemExpress · Cat: HY-116423A
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medchemexpress.com/jh295-hydrate.htmlCatalog No: HY-116423A
CAS No: 2714087-26-8
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 Nek2 inhibitor with an IC50 of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint. JH295 hydrate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition CuAAc with molecules containing Azide groups.
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