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JMJD3/HDAC-IN-1
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JMJD3/HDAC-IN-1

HY-156094 · 50 mg

MedChemExpress · Cat: HY-156094

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Catalog No: HY-156094
CAS No: 2883046-06-6
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

JMJD3/HDAC-IN-1 compound A5b is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 JMJD3 and histone deacetylase HDAC1, IC50=16 nM . JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion.

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