GENERAL CATALOGUE
JMS-053
HY-135457 · 1 mg
MedChemExpress · Cat: HY-135457
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medchemexpress.com/jms-053.htmlCatalog No: HY-135457
CAS No: 1954650-11-3
Category: Metabolic Enzyme Protease
Pack Size: 1 mg
Brand: MedChemExpress
Description
JMS-053 is an efficient and reversible PTP4A3 inhibitor, with an IC50 value of 18 nM. JMS-053 demonstrates broad PTP4A inhibitory activity with IC50s of 50 nM and 53 nM for PTP4A1 and PTP4A2, respectively. JMS-053 exhibits IC50 values of 92.6 nM and 207.6 nM for CDC25B and DUSP3, respectively. JMS-053 can effectively inhibit the activity of PTP4A3, inhibit tumor cell proliferation and migration through multiple mechanisms such as interfering with RhoA and STAT3/p38 signaling pathway. JMS-053 can be used for the study of cancers such as ovarian cancer, breast cancer and colon cancer.
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