GENERAL CATALOGUE
JN122
HY-163083 · 50 mg
MedChemExpress · Cat: HY-163083
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Manufacturer product page
medchemexpress.com/jn122.htmlCatalog No: HY-163083
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
JN122, a spiroindoline-containing molecule, is a MDM2 inhibitor. JN122 Inhibits MDM2/p53 proteinAAasAasAaprotein interaction and exerts robust in vivo antitumor efficacy. JN122 has antiproliferative activity in HCT-116 cells and HEK-293 cells with IC50 values of 39.6 nM and 4.28?M, respectively. JN122 can promote activation of p53 and its target genes, inhibited cell cycle progression, and induced cell apoptosis.
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