GENERAL CATALOGUE
JNJ-1013
HY-153188 · 5 mg
MedChemExpress · Cat: HY-153188
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Catalog No: HY-153188
CAS No: 2597343-08-1
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKB?, pSTAT3 Tyr705 Pink: ligand for target protein HY-138834 ; black: linker HY-Y1760 ; Blue: E3 ligase ligand HY-112078 .
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