GENERAL CATALOGUE
JNJ-39758979 dihydrochloride
HY-101189B · 50 mg
MedChemExpress · Cat: HY-101189B
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medchemexpress.com/jnj-39758979-dihydrochloride.htmlCatalog No: HY-101189B
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
JNJ-39758979 dihydrochloride is a selective, orally active, and high-affinity histamine H4 receptor antagonist, with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 dihydrochloride functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 dihydrochloride shows good anti-inflammatory and antipruritic activity.
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