GENERAL CATALOGUE
JNJ-8003
HY-149648 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-149648
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medchemexpress.com/jnj-8003.htmlCatalog No: HY-149648
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
JNJ-8003 is a potent and orally active non-nucleoside RSV polymerase inhibitor with an IC50 of 0.29 nM. JNJ-8003 targets the L protein polymerase complex of RSV IC50 = 0.67 nM , and blocks the transcription and replication of the viral genome by inhibiting the activity of RNA-dependent RNA polymerase RdRp . JNJ-8003 displays subnanomolar activity in vitro as well as prominent efficacy in mice and a neonatal lamb models. JNJ-8003 can be used for the study of respiratory syncytial virus RSV .
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