GENERAL CATALOGUE
JNJ28871063 hydrochloride
HY-103441 · 5 mg
MedChemExpress · Cat: HY-103441
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Manufacturer product page
medchemexpress.com/jnj28871063-hydrochloride.htmlCatalog No: HY-103441
CAS No: 944342-90-9
Category: JAK STAT Signaling
Pack Size: 5 mg
Brand: MedChemExpress
Description
JNJ28871063 hydrochloride is an orally active, highly selective and ATP competitive pan-ErbB kinase inhibitor with IC50 values of 22 nM, 38 nM, and 21 nM for ErbB1, ErbB2, and ErbB4, respectively. JNJ28871063 hydrochloride inhibits phosphorylation of functionally important tyrosine residues in both EGFR and ErbB2. JNJ28871063 hydrochloride crosses the blood-brain barrier and has antitumor activity in human tumor xenograft models that overexpress EGFR and ErbB2.
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