GENERAL CATALOGUE
JTE-607 free base
HY-110133A · 50 mg
MedChemExpress · Cat: HY-110133A
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medchemexpress.com/jte-607-free-base.htmlCatalog No: HY-110133A
CAS No: 188791-71-1
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-?, IL-1?, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 CPSF3 is the target of JTE-607 free base.
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