GENERAL CATALOGUE
JTE-607
HY-110133 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-110133
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Catalog No: HY-110133
CAS No: 188791-09-5
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-?, IL-1?, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 CPSF3 is the target of JTE-607.
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