GENERAL CATALOGUE
Jun12682
HY-157403 · 1 mg
MedChemExpress · Cat: HY-157403
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Catalog No: HY-157403
Category: Anti-infection
Pack Size: 1 mg
Brand: MedChemExpress
Description
Jun12682 is an orally active SARS-CoV-2 papain-like protease PLpro inhibitor, with a Ki value of 37.7 nM and an EC50 value of 1.1 ?M in the FlipGFP PLpro assay. Jun12682 has efficacy in hindering PLpro both deubiquitination and deISGylation, with Ki values of 63.5 and 38.5 nM, respectively. Jun12682 exhibits resistance in multiple PLpro mutant strains, and its enzymatic activity is comparable to that of the wild-type. Jun12682 can be used for the study of the SARS-CoV-2.
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