GENERAL CATALOGUE
JV8
HY-173433 · 50 mg
MedChemExpress · Cat: HY-173433
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Manufacturer product page
medchemexpress.com/jv8.html
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Catalog No: HY-173433
CAS No: 2841716-61-6
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
JV8 is a BRD4 PROTAC degrader. JV8 promotes the ubiquitination and degradation of BRD4 and induces apoptosis. JV8 has antitumor activity in a mouse 4T1 orthotopic tumor model. Pink: BRD4 ligand HY-78695 ; Blue: E3 ligase VHL ligand HY-173435 ; Black: Linker HY-33366 ; E3 ligase VHL ligand-linker conjugate HY-173436 .
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