GENERAL CATALOGUE
K284-6111
HY-148013 · 5 mg
MedChemExpress · Cat: HY-148013
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medchemexpress.com/k284-6111.htmlCatalog No: HY-148013
CAS No: 702668-62-0
Category: Immunology Inflammation
Pack Size: 5 mg
Brand: MedChemExpress
Description
K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-?B pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of I?B. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins eg: iNOS, COX-2, GFAP, and Iba-1 . K284-6111 reduces atopic-like skin inflammation and inhibits LPS HY-D1056 -induced liver injury. K284-6111 can be used for the study of Alzheimers diseases and sepsis like hepatic injury.
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