Kaempferol 3-O-sophoroside

Description

Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor TLR 2/4 for High mobility group box 1 HMGB1 , and it also exerts anti-inflammatory effects by blocking the activation of NF-?B expression and the production of TNF-?. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor BDNF and enhances autophagy by binding to AMP-activated protein kinase AMPK , thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases.