GENERAL CATALOGUE
KB-0118
HY-176535 · 50 mg
MedChemExpress · Cat: HY-176535
Reach 3+ verified distributors
Manufacturer product page
medchemexpress.com/kb-0118.html
Sponsored
Catalog No: HY-176535
CAS No: 2648377-08-4
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
KB-0118 BBC0115 is an orally active BET bromodomain inhibitor. KB-0118 selective binds to BRD2 and BRD4 over BRD3, with Kd values of 36.7 ?M for BRD2 BD1 and 47.4 ?M for BRD4 BD1. KB-0118 inhibits pro-inflammatory cytokines, including TNF, IL-1?, and IL-23a and selectively suppresses Th17 cell differentiation. KB-0118 modulates Th17-driven inflammation occurs through epigenetic suppression of BRD4, confirmed by downregulation of STAT3 and BRD4 target genes. KB-0118 has immunomodulatory effects in inflammatory bowel disease IBD model.
More from MedChemExpress
H
hsa-miR-4268 antagomir
HY-RI00947A
Epigenetics
H
hsa-miR-4731-5p antagomir
HY-RI01332A
Epigenetics
F
FRMD3 Human Pre-designed siRNA Set A
HY-RS05100
Epigenetics
M
MAPK12 Human Pre-designed siRNA Set A
HY-RS08101
Epigenetics
N
NEURL1 Human Pre-designed siRNA Set A
HY-RS09219
Epigenetics
L
LRFN2 Human Pre-designed siRNA Set A
HY-RS07782
Epigenetics
Luteolin 7-sulfate
HY-N6901
Epigenetics
VRTN Human Pre-designed siRNA Set A
HY-RS15705
Epigenetics