GENERAL CATALOGUE
KB-15
HY-175542 · 50 mg
MedChemExpress · Cat: HY-175542
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medchemexpress.com/kb-15.html
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Catalog No: HY-175542
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
KB-15 is a STAT3 inhibitor. KB-15 exhibits potent anti-proliferative activity against AGS gastric cancer cells IC50 = 0.29 ?M and BGC-823 gastric cancer cells IC50 = 0.65 ?M . KB-15 exerts anti-tumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular ROS accumulation. KB-15 induces G0/G1 phase cell cycle arrest and apoptosis, as well as suppresses colony formation and migration of gastric cancer cells. KB-15 demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model. KB-15 can be used for the study of gastric cancer.
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