KCL-286

Description

KCL-286 C286 is an orally active and brain-penetrant retinoic acid receptor RAR ?2 agonist EC50 = 1.9 nM . KCL-286 targets RAR?2 with good selectivity over RAR ? EC50 = 26 nM and RAR ? EC50 = 11 nM . KCL-286 activates RAR?2 in the injured neurons. KCL-286 induces axonal regeneration of both spinal and sensory nerves through the inhibitory environment of the CNS, modulates neuroinflammation and extracellular matrix molecules. KCL-286 can modulate the expression of CSPGs by neuronal secretion of decorin which promotes myelination and aids axonal growth. KCL-286 can be studied in research for area such as spinal cord injury and traumatic nerve injury.