KD-Validated AIFM1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated AIFM1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:AIFM1; Apoptosis Inducing Factor Mitochondria Associated 1; AIF; CMTX4; DFNX5; PDCD8; Apoptosis-Inducing Factor, Mitochondrion-Associated, 1; Programmed Cell Death 8 (Apoptosis-Inducing Factor); Apoptosis-Inducing Factor 1, Mitochondrial; Auditory Neuropathy, X-Linked Recessive 1; AUNX1; NAMSD; Neuropathy,Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome); Apoptosis Inducing Factor, Mitochondria Associated 1; Striatal Apoptosis-Inducing Factor; Testicular Secretory Protein Li 4; Programmed Cell Death Protein 8; EC 1.6.99.-; COXPD6; SEMDHL; CMT2D; COWCK; NADMR Background: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015] Research Area: Cell Biology,Epigenetics and Nuclear Signaling,Cancer,Metabolism,Neuroscience