KD-Validated APBB1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated APBB1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:APBB1; Amyloid Beta Precursor Protein Binding Family B Member 1; FE65; RIR; Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65); Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1; Adaptor Protein FE65a2; Stat-Like Protein; Protein Fe65; MGC:9072; Fe65 Background: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012] Research Area: Neuroscience,Signal Transduction