KD-Validated APE1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated APE1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:APEX1; Apurinic/Apyrimidinic Endodeoxyribonuclease 1; REF1; HAP1; APEN; APE; APX; REF-1; APE-1; APEX; APEX Nuclease (Multifunctional DNA Repair Enzyme); DNA-(Apurinic Or Apyrimidinic Site) Endonuclease; Apurinic-Apyrimidinic Endonuclease 1; Redox Factor-1; APE1; APEX Nuclease (Multifunctional DNA Repair Enzyme); Deoxyribonuclease (Apurinic Or Apyrimidinic); Apurinic/Apyrimidinic (Antibodyasic) Endonuclease; DNA-(Apurinic Or Apyrimidinic Site) Lyase; AP Endonuclease Class I; AP Endonuclease 1; Protein REF-1; APEX Nuclease; EC 4.2.99.18; EC 3.1.11.2; AP Lyase Background: The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019] Research Area: Epigenetics and Nuclear Signaling,Cardiovascular