KD-Validated ATM Serine/Threonine Kinase Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated ATM Serine/Threonine Kinase Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:ATM; ATM Serine/Threonine Kinase; Ataxia Telangiectasia Mutated; TELO1; TEL; Serine-Protein Kinase ATM; A-T Mutated; EC 2.7.11.1; ATDC; ATA; ATC; ATD; Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C And D; TEL1, Telomere Maintenance 1, Homolog (S. Cerevisiae); TEL1, Telomere Maintenance 1, Homolog; Serine/Threonine Kinase AT; AT Mutated; AT1; ATE Background: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] Research Area: Epigenetics and Nuclear Signaling,Cancer