KD-Validated ATP2A2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated ATP2A2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:ATP2A2; ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2; SERCA2; Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2; Calcium Pump 2; ATP2B; Endoplasmic Reticulum Class 1/2 Ca(2+) ATPase; SR Ca(2+)-ATPase; DAR; Calcium-Transporting ATPase Sarcoplasmic Reticulum Type, Slow Twitch Skeletal Muscle Isoform; ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2; ATPase Ca++ Transporting Cardiac Muscle Slow Twitch 2; ATPase, Ca++ Dependent, Slow-Twitch, Cardiac Muscle-2; Cardiac Ca2+ ATPase; EC 7.2.2.10; EC 3.6.3.8; EC 3.6.3; DD Background: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019] Research Area: Neuroscience