KD-Validated ATRX Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated ATRX Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2,500 Alternative Names of Immunogen:ATRX; ATRX Chromatin Remodeler; XH2; XNP; Transcriptional Regulator ATRX; ATP-Dependent Helicase ATRX; X-Linked Nuclear Protein; X-Linked Helicase II; RAD54L; MRX52; RAD54; JMS; Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 (S. Cerevisiae) Homolog); Alpha Thalassemia/Mental Retardation Syndrome X-Linked; Mental Retardation, X-Linked 52; RAD54 Homolog (S. Cerevisiae); Juberg-Marsidi Syndrome; EC 3.6.4.12; EC 3.6.1; ZNF-HX; Znf-HX Background: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017] Research Area: Epigenetics and Nuclear Signaling