KD-Validated BAG Cochaperone 3 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated BAG Cochaperone 3 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,M and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:BAG3; BAG Cochaperone 3; BAG Family Molecular Chaperone Regulator 3; BCL2 Associated Athanogene 3; Bcl-2-Binding Protein Bis; Docking Protein CAIR-1; BAG-3; BIS; Bcl-2-Binding Protein BIS Transcript 2; Bcl-2-Associated Athanogene 3; BCL2-Binding Athanogene 3; CAIR-1; MFM6 Background: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] Research Area: Cell Biology,Cancer,Metabolism