KD-Validated BCAR1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated BCAR1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:BCAR1; BCAR1 Scaffold Protein, Cas Family Member; CASS1; CAS; Cas Scaffolding Protein Family Member 1; CRKAS; Breast Cancer Anti-Estrogen Resistance Protein 1; BCAR1, Cas Family Scaffolding Protein; BCAR1, Cas Family Scaffold Protein; P130Cas; Breast Cancer Anti-Estrogen Resistance 1; Crk-Associated Substrate P130Cas; Crk-Associated Substrate; CRK-Associated Substrate; P130CAS; P130cas; Crkas; CAS1 Background: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017] Research Area: Signal Transduction,Cancer