KD-Validated Bridging Integrator 1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Bridging Integrator 1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:BIN1; Bridging Integrator 1; Myc Box-Dependent-Interacting Protein 1; Amphiphysin II; SH3P9; AMPH2; AMPHL; Box-Dependent Myc-Interacting Protein 1; Amphiphysin-Like Protein; Amphiphysin; Box Dependant MYC Interacting Protein 1; CNM2 Background: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016] Research Area: Cell Biology,Microbiology,Epigenetics and Nuclear Signaling,Cancer,Neuroscience