KD-Validated c-Kit Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated c-Kit Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000 Alternative Names of Immunogen:KIT; KIT Proto-Oncogene, Receptor Tyrosine Kinase; SCFR; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog; Mast/Stem Cell Growth Factor Receptor Kit ; CD117 ; PBT; Tyrosine-Protein Kinase Kit; Piebald Trait Protein; Proto-Oncogene C-Kit; EC 2.7.10.1; P145 C-Kit; C-Kit; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein ; Proto-Oncogene Tyrosine-Protein Kinase Kit; C-Kit Protooncogene; Piebald Trait; CD117 Antigen ; EC 2.7.10; MASTC; C-KIT Background: This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020] Research Area: Immunology,Tags & Cell Markers,Signal Transduction,Neuroscience,Stem Cells,Cancer,Developmental Biology,Neuroscience