KD-Validated C-Terminal Src Kinase Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated C-Terminal Src Kinase Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:CSK; C-Terminal Src Kinase; CSK, Non-Receptor Tyrosine Kinase; Tyrosine-Protein Kinase CSK; Protein-Tyrosine Kinase CYL; C-Src Tyrosine Kinase; C-Src Kinase; EC 2.7.10.2; EC 2.7.10 Background: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017] Research Area: Signal Transduction,Neuroscience