KD-Validated Catechol-O-Methyltransferase Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Catechol-O-Methyltransferase Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:COMT; Catechol-O-Methyltransferase; Catechol O-Methyltransferase; EC 2.1.1.6; Epididymis Secretory Sperm Binding Protein Li 98n; Testicular Tissue Protein Li 42; HEL-S-98n Background: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] Research Area: Neuroscience,Signal Transduction,Metabolism