KD-Validated Coenzyme A Synthase Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Coenzyme A Synthase Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:COASY; Coenzyme A Synthase; NBP; Bifunctional Coenzyme A Synthase; CoA Synthase; DPCK; PPAT; POV-2; Bifunctional Phosphopantetheine Adenylyl Transferase/Dephospho CoA Kinase; Phosphopantetheine Adenylyltransferase / Dephosphocoenzyme A Kinase; Nucleotide Binding Protein; NBIA6; PCH12; UKR1 Background: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014] Research Area: Signal Transduction,Metabolism