KD-Validated CRTC2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated CRTC2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:100-1:1,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:CRTC2; CREB Regulated Transcription Coactivator 2; TORC2; CREB-Regulated Transcription Coactivator 2; TORC-2; Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 2; Transducer Of Regulated CAMP Response Element-Binding Protein 2; Transducer Of CREB Protein 2 Background: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010] Research Area: Signal Transduction,Neuroscience,Metabolism