KD-Validated CSE1L Rabbit Polyclonal Antibody

Description

EnkiLife offers the KD-Validated CSE1L Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:400-1:2,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:CSE1L; Chromosome Segregation 1 Like; XPO2; CAS; CSE1; Cellular Apoptosis Susceptibility Protein; Chromosome Segregation 1-Like Protein; Importin-Alpha Re-Exporter; Exportin-2; Exp2; Chromosome Segregation 1 (Yeast Homolog)-Like; CSE1 Chromosome Segregation 1-Like (Yeast); Epididymis Secretory Sperm Binding Protein; CSE1 Chromosome Segregation 1 Like; CSE1 Chromosome Segregation 1-Like; Cellular Apoptosis Susceptibility Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] Research Area: Cell Biology,Signal Transduction,Cancer