KD-Validated Cyclin Dependent Kinase 5 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Cyclin Dependent Kinase 5 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:2,000-1:10,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:CDK5; CRK6; Cell division protein kinase 5; EC 2.7.11.22; PSSALRE; TAU protein kinase II catalytic subunit; TPKII catalytic subunit; Tau protein kinase II catalytic subunit; kinase Cdk5 Background: This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] Research Area: Cell Biology,Neuroscience,Cancer,Metabolism