KD-Validated Cyclin Dependent Kinase Inhibitor 1B Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Cyclin Dependent Kinase Inhibitor 1B Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:CDKN1B; Cyclin Dependent Kinase Inhibitor 1B; KIP1; P27KIP1; Cyclin-Dependent Kinase Inhibitor 1B (P27, Kip1); Cyclin-Dependent Kinase Inhibitor 1B; Cyclin-Dependent Kinase Inhibitor P27; P27Kip1; CDKN4; MEN1B; MEN4; P27 Background: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014] Research Area: Cell Biology,Epigenetics and Nuclear Signaling,Cancer