KD-Validated Cyclin T1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Cyclin T1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:100-1:1,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:CCNT1; Cyclin T1; CYCT1; CCNT; Human Immunodeficiency Virus Type 1 (HIV-1) Expression (Elevated); Cyclin-T1; HIVE1; CDK9-Associated C-Type Protein; Cyclin C-Related Protein; MLLT10/CCNT1 Fusion; Cyclin-T; CycT1 Background: This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] Research Area: Microbiology,Cell Biology,Epigenetics and Nuclear Signaling,Immunology