KD-Validated DAB2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated DAB2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:100-1:1,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:DAB2; DAB Adaptor Protein 2; DOC-2; Differentially Expressed In Ovarian Carcinoma 2; Differentially-Expressed Protein 2; DAB2, Clathrin Adaptor Protein 2; Adaptor Molecule Disabled-2; Disabled Homolog 2; DOC2; Disabled (Drosophila) Homolog 2 (Mitogen-Responsive Phosphoprotein); Disabled Homolog 2, Mitogen-Responsive Phosphoprotein (Drosophila); Dab, Mitogen-Responsive Phosphoprotein, Homolog 2 (Drosophila); Disabled Homolog 2, Mitogen-Responsive Phosphoprotein; Dab, Mitogen-Responsive Phosphoprotein, Homolog 2 Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Research Area: Signal Transduction,Epigenetics and Nuclear Signaling